Abstract

ANTIBIOTIC RESISTANCE: A UNIVERSAL-SCALE COLLAPSE IN DRUG ADMIN

Jeyaraj Pandiarajan†, Thangaiyan Suganya and Muthukalingan Krishnan

Abstract

The development of resistance to all kinds of antibiotics in the sensitive bacterial pathogens is a major challenge to infectious disease medicine. The astonishing effects of antibiotics and origin of the genes associated with resistance has been a long mystery. There is growing evidence that the genes that make up this environmental resistome have the potential to be transformed to pathogens and indeed there is some evidence that clinically relevant resistance genes have originated in environmental microbes. Understanding the extent of environmental resistome and its mobilization into pathogenic bacteria is essential for the management and discovery of antibiotics.

Keywords: Antibiotic resistance, Drug administration, Environmental resistome, Host resistance, Efflux.