Abstract

COMPARATIVE ANTIMICROBIAL AND HEMATOLOGICAL ACTIVITY OF DIFFERENT LEAVES AND RHIZOME EXTRACT OF CURCUMA LONGA

Dr. Giri Akhand Rachana*, Akhand Pooja and Dr. Pathak A.K

Abstract

In present study anti bacterial activity of three extract of Curcuma Longa i.e. 95% ethanolic leaf extract, Aqueous Leaf Extract, 95% ethanolic rhizome extract was monitored using disc diffusion method. Activity was determined by noting the zone of inhibition around the disc. A Gram negative & Gram positive bacterial strains (5 strains of each) used. Antibacterial activity of three extract of Curcuma Longa was checked against these bacterial strains. The study reveals that the 95% ethanolic leaf and rhizome extract at a concentration 12.5mg/ml were effective against Gram negative bacterial strain. 95% ethanolic leaf extract show better antibacterial activity then the rhizome extract against the Enterobacter aerogens and Streptobacillus monaliformus (Gram negative) and streptococcus epidermis (Gram positive) bacterial strains and show no activity against three Gram positive bacteria (Streptococcus pyrogens, Streptococcus aureus, and Streptococcus pneunoniae) and Gram negative (Escherichia coli) .Aqueous leaf extract exhibited no significant activity against the Gram negative and Gram positive bacterial strains. To drugs Antibiotic Cefotaxime and Amikacin used as a control for anti bacterial activity against Gram negative and Gram positive bacteria in the present set of studies.

Keywords: Curcuma Longa, Hematological, Anti bacterial activity, Gram Negative and Gram Positive Bacteria. Disc Diffusion.