Abstract

“FORMULATION, DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF PRASUGREL HYDROCHLORIDE”

R. Margret Chandira*, P. Palanisamy, B.Jaykar, A.Pasupathi, N. K. K. Sreedharan, Debjit Bhowmic

Abstract

The aim of present investigation wss to develop immediate release formulation of Prasugrel Hydrochloride for oral drug delivery by using suitable concentration of superdisingrants. Croscarmellose sodium (AC-DI-SOL), povidone, MCC, Magnesium stearate was used to formulate the immediate release tablet. Croscarmellose sodium was used as superdisintegrant and povidone was used as a binder to control the release of drug. Special care was taken for Prasugrel Hydrochloride processing in low humidity condition and geometric mixing is applied to avoid content uniformity and segregation. The flow properties of the powdered blend for all the batches were found to be good and free flowing. The weight variation, hardness and friability of all the formulated tablets within the specified requirements. The disintegration times for the formulated tablets are within the range of USP. For Prasugrel Hydrochloride tablets direct granulation was method of choice. Results found that release profile of batch no.F6 matches with Innovator product. The Percentage cumulative drug release of batch. No. F6 was found at 30 Minutes 103.12%.

Keywords: Prasugrel Hydrochloride, Immediate release, Croscarmellose sodium, povidone.