Abstract

FORMULATION OF BUPROPION HCL PRESS COATED TABLETS FOR PULSATILE DELIVERY AND INVITRO EVALUATION

*Rasheed Shaik, Lakshmi Niharika Kinnera, Venkata Vinod Kumar Gajula

Abstract

Development and evaluation of bupropion press coated tablets via core tablets comprising of polymers such as Ethyl cellulose, HPMC K4M and super disintegrants including lycoat and Ludiflash is what this study sets out to achieve. It can be reasonably stated that TC3 of core tablet was considered and prepared formulations PD1-PD5, from these preparations of coated tablet, PD5 was chosen as optimized formulation for designing a Pulsatile Device since repeatable results were obtained from trails of core and press coated tablets. This was due to the fact that among TC1-TC8 formulations, TC3 had the highest percentage drug release of 96.42% at 40 minutes. Thus, it has been proved that press coated bupropion can be used as time dependent chronopharmaceutical preparation. On this basis, it can be finally concluded that pulsatile drug delivery system for bupropion can be developed using ethyl cellulose and HPMC K4M.

Keywords: Bupropion, Pulsatile Delivery, ludiflash, Lycoat, Ethyl cellulose & HPMC K4M.