Abstract

ATTENUATION OF BIOCHEMICAL PARAMETERS OF SHOREA ROBUSTA LEAVES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Velayutham Ravichandiran, Patil Vishal Satish* and BV Nagarjuna Yadav

Abstract

Shorea robusta belongs to family Dipterocarpaceae, traditionally is used to treat wounds, ulcers, leprosy, cough, gonorrhea, earache and headache and many more. Diabetes is associated with profound alterations in plasma lipid and lipoprotein profile and with an increased risk of coronary heart disease. The presence of phytochemicals such as tannins, alkaloids, proteins, flavonoids, triterpenes and saponins in the ethanolic extract/fractions was revealed by the preliminary phytochemical screening, keeping in view of medicinal importance the present study is an effort to investigate the biochemical parameters of m shorea robusta leaves in streptozotocin induced diabetic rats for 21 days.[1] The acute toxicity studies of oral doses of ethanolic leaves extract/fractions in rats revealed that it has a high safety profile, as the extract/fractions was well tolerated by the animals. The test drug was administered for 21 days at a four different dose level 100, 200 mg/kg for ethanolic extract and 100, 100mg/kg each of two successive fractions (chloroform and n-butanol) made in aqueous and given by orally. Body weight, urine sugar was analyzed before and after treatment of extract/fractions while serum glucose was analyzed every week and lipid and lipoprotein profile from serum was analyzed after 21 days. The ethanolic extract/fractions of Shorea robusta leaves significantly prevented loss of body weight and reduce urine sugar. The results indicated that the ethanolic extract/fractions produced significant (p < 0.001) in biochemical parameter.

Keywords: Shorea robusta, streptozotocin (STZ), total cholesterol, total glycerides.