Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF HIGHLY WATER SOLUBLE ANTI-DIABETIC DRUG METFORMIN HCL

Khushi Singh*, Rajkumar Mishra, Dr. Bhanu P. S. Sagar

Abstract

The current study demonstrated how bigels of natural gums and polymers (Chitosan with Karaya gum, locust bean gum, and Guar gum) might be used to regulate the drug's release from the body. The results of this study show that all three of the gums used in our investigation were shown to be good candidates for regulating the release of highly water-soluble drugs through this mechanism. As a result, they can be effectively used to formulate sustained release matrix tablets. By using diffusion in conjunction with an erosion mechanism, this delivery system aims to lower the frequency of administration. Furthermore, it was discovered that CH-Karaya gum released more drugs than Guar and Locust bean gum. Consequently, it is evident that using bigels of gum rather than pure gum can be a novel way to delay the release of drugs.

Keywords: Chitosan, guar gum, karaya gum, locust bean gum, metformin HCL, natural gums, sustained release.