Abstract

THE RECENT DEVELOPMENTS ON GASTRIC FLOATING DRUG DELIVERY SYSTEMS: AN OVERVEIW

Sanjay Dantoriya *, Govind Bhandari, Suresh Chandra Mahajan, Pooja Mishra

Mahakal Institute of Pharmaceutical studies, Ujjain (M.P), India.

Abstract

The concept behind the development of novel delivery system in certain drawback of conventional dosages form and to over come the certain aspect related to physicochemical properties of drug molecule and related the formulation development. Controlled release floating drug delivery system is a promising delivery system for a drug candidate having limited absorption window sparingly soluble and insoluble drugs, drugs those locally release in stomach and shows degradability in colon or poor colonic absorption. This review entitled the detailed scenario related to floating drug delivery system with their advantages over the conventional drug delivery system and limitation, which are helpful in development of dosages form, from the formulation an technological point of view, the floating drug delivery system is considerably easy and logical approach. An attempt has been made in this review article to introduce the readers to the current technological developments in floating drug delivery system by approaches to design single-unit and multiple unit floating systems , physiological and formulation variables which affect the gastric retention ,their classification and formulation aspects , Micromeritic properties to evaluate the performance and application of floating system, patented delivery systems , marketed products and the development of a pharmaceutical dosage forms covered in detail.

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