Abstract

EVALUATION OF IN VIVO ANTI-INFLAMMATORY ACTIVITY OF PERGULARIA DAEMIA

Sridevi G, Prema Sembulingam, Sembulingam K*, Srividya S, Muhammed Ibrahim

Abstract

Pergularia Daemia (PD) is a medicinal herb and used as folk medicine by the villagers. In our earlier study, the anti-inflammatory activity of PD extract was evaluated by in vitro method through membrane stabilization test and protein denaturation test and the results were encouragingly positive. Hence, in the present study, the anti inflammatory activity of the ethanol extract of PD was evaluated by in vivo methods viz., formalin induced inflammation and acetic acid induced writhing test in albino rats. The results showed that the formalin induced paw licking movements were decreased (nonsignificant) in the early phase (0-10 mins) but significantly decreased in the late phase (10-20 mins). The number of acetic acid induced abdominal constrictions significantly reduced after PD extract administration at the doses of 200 mg.kg and 300 mg/kg. The effect of the ethanol extract of PD was comparable with standard non-steroidal anti inflammatory drug viz. diclofenac sodium. Thus our results encourage to recommend and justify the use of the PD extract for the treatment of painful and inflammatory conditions.

Keywords: Anti-inflammatory, abdominal writhing, paw licking, In-vivo, Pergularia daemia.