Abstract

A REVIEW ON HYDROGEL DRUG DELIVERY SYSTEMS WITH SPECIAL REFERENCE TO TOBRAMYCIN ANTIMICROBIAL ACTIVITY

*Miss. Tamboli Muskan A., Mr. Survase Abhijeet B.

Abstract

Hydrogel-based biomaterials play a significant role in enhancing the effectiveness of skin wound healing applications. This article examines hydrogel instruments designed for biomedical use. This paper begins with a detailed theoretical overview of how hydrogels are synthesized and function. This segment focuses heavily on crosslinking methodologies and operational principles. The second part focuses on hydrogel applications. Hydrogels consist of three-dimensional, cross-linked polymer chains that absorb and trap massive amounts of water in their internal spaces. Practically any water-soluble polymer can form a hydrogel, offering a broad spectrum of chemical compositions and physical properties. Moreover, hydrogels can take multiple physical shapes, including slabs, micro/nanoparticles, coatings, and films. They are often used to deliver tobramycin, an aminoglycoside antibiotic derived from fermenting Micromonospora purpurea or M. echinospora. It consists of a mixture of three main factors: C1, C1a, and C2. Tobramycin is typically formulated as a sulfate salt. Each constituent contains five basic amine groups, necessitating five equivalents of sulfuric acid per mole of the tobramycin free base.

Keywords: Tobramycin, Anti-microbial activity, Hydrogel, Wound healing, Pseudomonas aeruginosa.