Abstract

DEVELOPMENT AND EVALUATION OF A EUTECTIC-BASED SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM FOR SOLUBILITY AND PERMEATION

^*Marne Gandharva Anil, Miss. Shraddha Madan Khaladkar

Abstract

The medicine Ibuprofen does not work well when taken by mouth because it does not mix well with water. This is a problem. Ibuprofen is a type of medicine that's hard to dissolve in water, which is why it is called a Biopharmaceutics Classification System Class II agent. Traditional ways of giving Ibuprofen like Self-Micro emulsifying Drug Delivery Systems have some issues. They need a lot of ingredients that are not the actual medicine, which can be up to 80 percent of the total. This means the pills are big and people do not like taking them. This study is trying something by using a lot fewer extra ingredients. It uses a liquid called a Therapeutic Deep Eutectic Solvent as the main part of the medicine. Ibuprofen was mixed with L-Menthol to make a liquid that has the medicine in it. This liquid was then made into a Self-Micro emulsifying Drug Delivery System using Polysorbate 80 and Polyethylene Glycol 400. Then it was turned into a solid by adding it to Aerosol 200. The new Solid-SMEDDS, called F5 has a lot of Ibuprofen in it which is 42.5 percent of the weight. When we looked at the Therapeutic Deep Eutectic Solvent, we found that it has a density of 1.144 grams per centimetre and a viscosity of 894.7 millipascal-seconds. We did some tests. Found that the medicine mixes with water very quickly in about 48 seconds. When we tested how well the medicine comes out of the Solid-SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM we saw that most of it comes out within 15 minutes. We also did a test using tissue from a pig and found that the medicine gets through the tissue much better which is 5.8 times more, than before. This study is important because it provides a way to give medicines like Ibuprofen that do not mix well with water. This new way is robust and cost-effective.

Keywords: Ibuprofen, Therapeutic deep eutectic solvent, Self-micro emulsifying drug delivery system, Solid-smedds, L-menthol, Aerosol 200.