Abstract

3D PRINTING APPLICATION IN TRANSDERMAL DRUG DELIVERY SYSTEM

Harshil Soni*, Hitesh Jain, Yagnesh Modi, D. B. Meshram

Abstract

The application of three-dimensional printing as a manufacturing technique for advanced transdermal delivery devices is examined in existing literature. Three-dimensional printing refers to a variety of technologies that use computer-generated images to generate a physical object using machine-controlled tools. This method of additive manufacturing makes use of CAD designs to create physical objects through the layering process that is controlled numerically, thus allowing for the creation of intricate micro structures. The three-dimensional (3D) printing techniques used in the manufacturing process of MNs include SLA (Stereolithography), 2PP (two photon Polymerization), FDM (Fused Deposition Modelling), DLP (Digital light processing), and CLIP (Continuous liquid interface production). Compared to other traditional methods like micromolding, lithography, and etching, which are expensive and have multiple steps involved in their manufacturing process, 3D printing is advantageous for its design freedom, material savings, affordability, ease of making prototypes, and application for personalized medicine by customizing drug dosage per individual needs. Many types of MNs can be fabricated, such as solid, hollow, dissolving, coated, and hydrogel-forming MNs.

Keywords: 3D Printing Microneedles; Patches; Inkjet printing; Transdermal drug delivery systems.