Abstract

SYNTHESIS, ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY OF NOVEL PYRAZOLINES DERIVATIVES

N.V.Shitole, S.B.Ade and S.M.Lonkar*

Abstract

A simple, clean and efficient method has been developed for synthesis of novel 3-(-2'-hydroxy substituted phenyl)-5-(2'-hydroxy substituted phenyl)-2-pyrazoline and N-phenyl pyrazolines are synthesized by refluxing polyhydroxy chalcones with hydrazine hydrate or phenyl hydrazine in ethanol for 3-4 hours. An excellent yield (70-78%) was obtained. This method gives remarkable advantages such as mild reaction conditions, less reaction times, excellent yields and involves the nonchromatographic isolation procedure. The compounds were found to have antibacterial and antifungal activitity.

Keywords: Polyhydroxy chalcones, Hydrazine hydrate, Phenyl hydrazine and biological activity.