Abstract

SYNTHESIS OF MANNICH BASES AND SCREENING FOR ANTIMICROBIAL ACTIVITY

Dr. Ravi Malhotra*

Abstract

In an attempt to develop new analeptics mannich bases are synthesized in which main nucleus remained camphor while different secondary amines are added as subsituents. It is observed that existing analeptic (doxapram) have close resemblance with our newly synthesized series in one way or another as compound shows promising results in our studies ; as respiratory and circulatory stimulant have substituent piperidine which is very close to substituent morpholine in doxapram. The IR and NMR studies were conducted for the confirmation of the chemical structure of the final product. But in present studies we have concentrated on its anti – microbial activity.

Keywords: mannich bases, piperidine, biological evaluation, camphor, formaldehyde.