Abstract

MICROBIOLOGICAL SENSITIVITY PATTERNS IN RESPIRATORY TRACT INFECTIONS; A PROSPECTIVE OBSERVATIONAL STUDY

Ashok Kumar. D, Krupa Sagar. N, B. Sarada, Mallesh. M, M. Venkata
Subbaiah and M.Purushothaman

Abstract

A respiratory tract infection is an infection anywhere in the respiratory tract. This study summarizes that surveillance of the bacteria isolated from patients over prolonged periods not only can provide important information for day-to-day decision making in antimicrobial therapy in individual hospitals . Out of 527 patients 347 (65.84%) were males and 180 (34.15%) females(34.15%). Minimum of 70 (13.28 %) were in 30 – 40 age group, 447 (84.81%) were shown growth and 80 (15.18 %) have not shown growth of any isolates. 93 % of Kp sp. isolated were sensitive to AZM and 9% were sensitive to AMX. And about 7% of Kp sp. isolated were resistant to AZM and 91 % were resistant to AMX. Ec showed 100 % sensitivity to AZM and 100 % resistance to CIP, GEN, COT, CTX and AMX. Pa showed 100 % sensitivity to GEN and 0% sensitive to P and AMX. S. p showed about 91% sensitive to CIP and 14% were sensitive to AMX. And about 8% of S. p isolated was resistance to CIP and 85% resistance to AMX. Sal showed about 100% sensitive to CTX, P and 0% to AMX. Sau showed about 100% sensitive to GEN and 0% sensitive to P, AMX. Over all sensitivity and resistance of GEN was 92.78%, 7.22% respectively. Similarly CIP was 84.32%, 15.68%; AZM was 80.54% and 19.46%, CTX 79.56%, 20.44%; COT 63.42%, 36.58%; P 27.39%, 72.61%; and AMX 9.77%, 90.23%. Antibiotic therapy was changed in 279(62.41%) of patients after culture report and antibiotic therapy was not changed in 168(37.58%) of patients after culture report. The study provides important data, which can help to guide physicians to choose the appropriate treatment regimen for RTI.

Keywords: Respiratory Diseases, Antibiotic Resistance, Clinical Pharmacist, Pharm. D.