Abstract

SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOLOGICAL STUDIES OF CU(II), CO(II) AND ZN(II) COMPLEXES DERIVED FROM QUINOLINE AND QUINAZOLINE MOIETIES

K. Siddappa*, C. V. Reddy and Sunilkumar B. Mane

Abstract

The condensation reaction between 2-methyl-4-oxoquinazoline - 3(4H)-carbothihydrazide with 2-hydroxyquinoline-3-carbaldehyde results in the formation of complexes of the type ML2 and Mï‚¢L [where M = Cu(II) and Co(II) Mï‚¢ =Zn(II)]. The formation of compounds were characterizations by elemental analysis, spectral (Uv-Visible, IR and NMR) and magnetic data. The synthesized compounds were tested for their antimicrobial activity against Gram positive and Gram negative bacterium as well as against fungi in order to check the biological potency.

Keywords: Quinazoline, quinoline, antimicrobial activity.