Abstract

PATTERN OF ANTIHYPERTENSIVE THERAPY AMONG DIABETIC HYPERTENSIVES

*Dr. Priya Mohan B. N and Dr. Basavaraj Bhandare

Abstract

Background: Diabetes is fast gaining the status of a potential epidemic in India with more than 62 million diabetic individuals currently. The incidence of hypertension in patients with T2DM is approximately two-fold higher than in age-matched subjects without the disease which increases macro and micro vascular complications and 7.2 fold rise in mortality. This study attempts to analyse the use of evidence based medicine in a tertiary care hospital. Objective: 1.To evaluate antihypertensive usage in patients with coexisting T2DM (type 2 diabetes) and compare with recent JNC 8 guidelines. Material & methods: A prospective observational study was conducted in RajaRajeaswari Medical College & Hospital from August 2014 to january 2015. A total of 150 cases with coexisting diabetes and hypertension were analysed. Relevant information was recorded in a structured proforma & data was evaluated. Results: In the present study 68% of the patients were in the age group 55-70yrs with male preponderance Among diabetic hypertensives, 38.67% of patients were treated with single anti-hypertensive drug and 61.33% of patients were treated with anti-hypertensive drug combinations. In monotherapy, Angiotensin Receptor Blockers(telmisartan) was most commonly prescribed. In combination therapy, calcium channel blockers (amlodipine) and Angiotensin Receptor Blockers(telmisartan) followed by calcium channel blockers (amlodipine) and beta blocker (atenolol) were used. In uncontrolled cases 3 drugs were used, calcium channel blockers (amlodipine), Angiotensin Receptor Blockers (telmisartan) and thiazide diuretics (hydrochlorthiazide). Conclusion: In our study antihypertensive polytherapy CCB’s+ARB’s was most commonly prescribed which was in accordance with JNC 8 report.

Keywords: Antihypertensive agents, Diabetes, Hypertension, Evidence based medicine.