Abstract

FORMULATION AND EVALUATION OF COLLAGEN-BASED QUERCETIN CREAM

Lanke Jahnavi, Manavelti Mounika, Medapati Sonia, Kusampudi Brundha Nisitha, Nagineni Sudarshan Rao*

Abstract

Background: Inflammation is a fundamental pathophysiological feature in numerous chronic diseases including arthritis, dermatitis, and wound-related conditions. Synthetic anti-inflammatory agents, though effective, are associated with significant adverse effects such as gastrointestinal bleeding, cardiovascular risks, and localized skin irritation. This has prompted renewed interest in plantderived therapeutics with safer profiles. Objective: The present study aimed to formulate and evaluate a collagen-based quercetin cream incorporating wool fat (lanolin) and cetostearyl alcohol for enhanced antioxidant protection, skin repair, and moisturization. Methodology: Four formulations (F1-F4) were developed with varying concentrations of quercetin (0.50- 2.00g) and collagen (0.50-1.00g), along with oleic acid as a penetration enhancer, wool fat as an emollient, cetostearyl alcohol as a stabilizing base, and suitable preservatives.

Keywords: Quercetin, Collagen, Wound Healing, Topical Cream, Anti-inflammatory.