Abstract

BIOCHEMICAL PROPERTIES ON CHEMOSENSITATION OF FERULIC ACID AND PACLITAXEL IN NON-SMALL CELLS LUNG CARCINOMA CELLS IN VITRO

J.P. Jose Merlina*, B. Venkadesha, R. Hussaina, Sheeja.S. Rajanb

aResearch Department of Zoology, Muslim arts college, Thiruvithancode, Tamilnadu, India.

bResearch Department of Zoology, St. Johns College, Palayamkottai, Tirunelveli, Tamilnadu,India.

Abstract

Ferulic acid (FA) is a phenolic phytonutrient, which possesses strong anticancer effect. However, its prominent application in cancer is limited due to poor bioavailability at the tumor site. Paclitaxel (PTX) is a semi synthetic drug which is used for cancer treatment. The aim of the study was to investigate the multidrug resistance of FA and PTX. It was noticed that anticancer potential of FA + PTX was greater than that of FA and PTX treatment alone. Further, FA + PTX exhibits increased TBARS, Catalase and SOD, altered GSH and GPx in NCIH460 cells when compared to bulk FA and PTX treatment alone. Our results indicate that FA + PTX demonstrated increased anticancer property in cancer cells than FA and PTX treatment alone.

Keywords: Ferulic acid (FA), Paclitaxel (PTX), Anticancer, Chemotherapy.