Abstract

HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY TO EVALUATION ESTROGEN, PROGESTRON AND HER2 RECEPTORS IN IRAQI BREAST CANCER WOMEN

Khalid Mahdi Salih, Iyden K. Mohammed, *Noor Al-Huda Ali A. H. Saeed, Enas Waleed Shakir, Maha Mohmmed Al-Sayyid

Abstract

Breast cancer is the most common malignancy worldwide and the first among the commonest cancers in iraq which is incidence rate at all ages in women and main cause of death in Iraq and worldwide women.This study was designed to shed the light about histological study and immunohistochemical evaluation of Estrogen, Progesterone,HER2 Receptors in the biopsies that obtained from 111 Iraqi Breast Cancer women to classify the tumor in different subtypes collected from different sites and hospitals for early detection of breast cancer and gynecology. during the period from July 2013 to October 2014. However, tissue biopsies were obtained from only malignant breast women after surgery and before therapies (Chemotherapy, radiotherapy or adjuvant). The results of histopathological examination showed majority of BC in Iraqi women included in this study was invasive breast carcinoma (92.8%) in which ductal invasive carcinoma (DIC) constitute 88.3% and lobular invasive carcinoma (ILC) about 4.5%, while the rest of BC 7.2% belong in-situ ductal carcinoma (ISDC). The clinical staging and grading of different types of BC showed the minority of ISDC were discovered at low grade (12.5%), while the majority were either at intermediate (50%) or high grade (37.5%) followed by DIC (15.3%) first stage and the rest at second stage (59.2%) or third stage (25.5%) . Similarly 20.4%of IDC at low grade and the rest were either was intermediate (51%) or high grade (28.6%). However, all LIC cases were second stage and intermediate grade (100%). The current study showed three subtypes of invasive carcinoma (molecular subtyping) Luminal-like carcinoma (80.6%), HER2-enriched carcinoma (9.7), and Basal-like carcinoma or also Known Triple negative TNBC (9.7%) and the differences was (P> 0.00006).

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