Abstract

AIR SUSPENSION AND SOLID DISPERSION TECHNIQUES FOR OBTAINING CONTROLLED DRUG DELIVERY SYSTEM CONTAINING KETOROLAC AND PANTOPRAZOLE

E.E. Zien El-Deen*, M.M. Ghorab, S. Gad, H.A. Yassin

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are important agents in the management of arthritic and inflammatory conditions, and are the most frequently prescribed medications. The present study reports on the formulation of ketorolac loaded Eudragit RS100, Eudragit RL100 as well as Ethyl cellulose as a controlled release drug delivery system. Solid dispersion and microencapsulation by air suspension method were the techniques for choice. One of the best choices to improve the GI safety is the co-medication of proton pump inhibitors (PPIs) with NSAID in one formula to suppress gastric acid. A fixed NSAID/PPI combination ensures expected protective effects by improving patients’ PPI adherence and physicians’ PPI prescription persistence. A fixed combination of enteric-coated ketorolac/pantoprazole formula has been studied. An accurate simple and précised method was adopted for simultaneous determination of ketorolac and pantoprazole in a physical mixture form. The method is based on measuring the first derivative amplitudes. The obtained results were validated for accuracy, precision, LOD, LOQ and were found to be satisfactory. The proposed method is simple, rapid and suitable for the assay of such combinations.

Keywords: Solid dispersion, Microencapsulation, Controlled released systems, Combination of NSAIDs and PPI, Drug delivery systems.