Abstract

FORMULATION AND IN VITRO EVALUATION OF SUMATRIPTAN SUCCINATE FAST DISSOLVING TABLETS

P.S.A.Chakravarthy

Venkateswara Institute of Pharmaceutical Sciences, Andhrapradesh. India

Abstract

Recent development in Fast disintegration tablets have brought convenience in dosing to elderly and children who have trouble in swallowing tablets. The objective of the present study was to prepare the Fast disintegration tablets of sumatriptan succinate, an anti migrane drug. As precision of dosing and patient compliance become an important prerequisite for a migrane treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and patient's acceptability. Hence, the present work was undertaken with a view to develop a fast disintegration tablet of sumatriptan succinate which offers a new range of product having desired characteristics and intended benefits. Various techniques like direct compression and sublimation technique were used to formulate Fast disintegration tablets of sumatriptan succinate. In direct compression method and sublimation method the effect of various super disintegrants was studied, among these 4% cross povidone showed better drug release. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulations were evaluated for in-vitro dissolution test. Amongst all the techniques sublimation technique was found to be most successful and tablets prepared by this technique (F12) had disintegration time of 30 sec. and % CR 52.74±1.42 after 5 min.

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