WJPR
World Journal of Pharmaceutical Research
( An ISO 9001:2015 Certified International Journal )
An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
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WJPR Citation
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| All | Since 2020 | |
| Citation | 8502 | 4519 |
| h-index | 30 | 23 |
| i10-index | 227 | 96 |
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Best Paper Award : Dr. Dhrubo Jyoti Sen
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Abstract
A NOVEL QUANTITATIVE ESTIMATION OF POORLY WATER SOLUBLE DRUG ATORVASTATIN BY USING HYDROTROPIC SOLUBILIZATION TECHNIQUE
1Pharmaceutical analysis, Nirmala college of pharmacy, Acharya Nagarjuna University, India 2Pharmaceutics, Nirmala college of pharmacy, Acharya Nagarjuna University, India 3Pharmaceutics, Nirmala college of pharmacy, Acharya Nagarjuna University, India 4Pharmaceutics, SIMS College of Pharmacy, Acharya Nagarjuna University, India 5HOD of Pharmaceutical chemistry, Nirmala college of pharmacy, Acharya Nagarjuna University, India
Abstract In the present research, hydrotropic solubility enhancement has been done helpful for soluble poorly water soluble anti hypertensive drug is atorvastatin. The hydrotropic substance is urea. This technique is reliable and simple. In the present study more than 2 folds solubility enhanced when compared to distilled water alone. The urea was used in different concentrations 10, 20,30,40,50 and 60mg. The drug and hydrotropic substance ratios were 1:1, 1:2, 1:3, 1:4, 1:5 and 1:6. The hydrotropic substance (urea) did not interfered in the analysis. The hydrotropic substances are freely available, less cost, pollutant free method. The hydrotropic solubility enhancement technique is very accurate, the solubility enhancement further helpful for improve bioavialabity of drug. Keywords: Atorvastatin, Urea, Hydrotropic technique, Solubity enhancement. [Full Text Article] [Download Certificate] |
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