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Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME COUMARINE-SCHIFFS BASE DERIVATIVE

Pravin Chowdhary, Ashish Asrondkar, Vrushali Patil, *Anil Bobade, Shashikant Vaidya.

Abstract

8-Hydroxycoumarine reacts with ethyl chloroacetate in the presence of anhydrous K2CO3 to yield ethyl [(2-oxo-2H-chromen-4-yl)oxy]acetate (1). The ethyl ester reacts with hydrazine hydrate and forms 2-[(2-oxo- 2H-chromen-4-yl)oxy]acetohydrazide (2). The hydrazide upon reaction with various substituted acetophenone yields substituted 2-[(2-oxo-2Hchromen- 4-yl)oxy]-N'-[(1E)-1-Phenylethylidene]acetohydrazide (3a-e). The newly synthesized compounds were assigned on the basis IR, MASS and 1H NMR spectral data. All the compounds have been screened for their antibacterial and antifungal activity by the cup-plate method. Some of the compounds showed good activity against all the organisms.

Keywords: Coumarine, Schiff bases, Hydrazones, Antibacterial, and Antifungal activity.


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