Abstract

MELT EVAPORATION METHOD: A SOLID DISPERSION STRATEGY TO ENHANCE SOLUBILITY AND DISSOLUTION OF LAFUTIDINE

*Abhishek. Y. Kanugo, Pratibha Chavhan , V.V. Potnis.

Kamla Nehru College of Pharmacy, Butibori, Nagpur, India.

Abstract

Lafutidine is a novel potent H2-receptor antagonist and very widely used during gastric ulcers, duodenal ulcers and stomach ulcers. Lafutidine is yellowish white crystalline powder practically insoluble in water. Due to very poor solubility, its bioavailability rate is limited by dissolution. In this study, an attempt has been made to enhance the solubility and dissolution of Lafutidine by melt evaporation, which is a solid dispersion technique by using polyethylene glycol. Various ratio of drug: carrier was prepared and further evaluated for its saturation solubility, drug content and rate of dissolution. Spectral characteristics were carried out by UV spectroscopy and FTIR. Among all the formulations, dispersion with PEG 6000 shown highest saturation solubility of 133.07 μg/ml and drug content as 99.67 %.

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