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Abstract

EFFECT OF DIFFERENT STABILIZERS ON THE FORMULATION OF SIMVASTATIN NANOSUSPENSION PREPARED BY PRECIPITATION ULTRASONICATION TECHNIQUE

*B. Narasimharao, V.Viswanath, M.Purushothaman, S.Sreevani, G. Sowjanya

Abstract

The objective of the present study was to formulate and evaluate nanosuspensions of Simvastatin, a poorly soluble drug in order to enhance its solubility and dissolution characteristics. Simvastatin is a Biopharmaceutical Classification System (BCS) Class II drug having very low solubility therefore low oral bioavailability. In this study Simvastatin nanosuspensions were prepared by precipitation technique followed by high frequency sonication by using a combination of different stabilizers. The formulated nanosuspensions were characterized by Scanning Electron Microscope (SEM) and FTIR. The formulations were evaluated for drug content, entrapment efficacy and In-Vitro dissolution. SEM results showed the particle size of the formulated nanosuspensions in nanosize. FTIR spectrum revealed that there are no interactions between drug and carriers. The effect of particle size was found to be significant on the saturation solubility of the drug and in-vitro drug release studies showed significant increase in the dissolution rate of nanosuspensions as compared with pure drug.

Keywords: Simvastatin, Nanosuspension, Precipitation– Ultrasonication, Bioavailability, Solubility enhancement.


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