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Abstract

DESIGN AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LORNOXICAM

Senthil Kumar K*, Ameer Basha Pothuganti, Mohammed Gulzar Ahmed

Abstract

The aim of the present work was to develop sustained release matrix tablets of Lornoxicam using polymers such as carbopol, Eudragit RS100, polyvinylpyrrolidone, ethyl cellulose, pectin as carriers in various concentrations. Matrix tablets were prepared by direct compression method. Prepared formulations were subjected to various evaluation parameters like hardness, friability, thickness, % drug content, weight variation etc. In-vitro dissolution studies were carried out for 12 hrs. The tablets were subjected to in-vitro drug release in 1.2 pH for first 2 hrs then followed by 6.8 pH phosphate buffer for next 10 hrs and the results showed that among the ten formulations F2 and F4 showed good dissolution profile to control the drug release respectively. Combination of polymers shows greater retarding of drug release. The compatibility of the drug and polymer were determined by FT-IR spectroscopy. Results showed that the drug was compatible with all polymers. The release data was fitted to various mathematical models such as Higuchi, Korsmeyer-peppas, Hixson crowell, Zero order and first order to evaluate the kinetics of drug release. The drug release follows mixed order kinetics and mechanism was found to be non-fickian diffusion. The stability studies were carried out according to the ICH guideline which indicates the selected formulation (F2 & F4) was stable. In conclusion, the results suggest that the developed matrix tablets of Lornoxicam shows to improved efficacy and better patient compliance.

Keywords: Sustained release, Matrix tablets, Lornoxicam, carbopol, Eudragit RS100, Polyvinylpyrrolidone, Ethylcellulose, pectin.


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