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Abstract

FORMULATION AND EVALUATION OF BILAYERED TABLET OF CAPTOPRIL AND GLIMIPERIDE

Fatima Sultana* and R. Balaji Reddy

Abstract

Objective: Diabetes mellitus generally accompanied with major complications like Hypertension, Cardio myopathy, Stroke, Hyperlipidemia, Ischemic cerebrovascular disease, and Peripheral vascular disease. These conditions account for most morbidity and mortality among middle-aged and older people. The drug of choice for type2 diabetes mellitus is glimiperide and for Hypertension is captopril, to reduce the prevention of cardiac problems in diabetic patients. The objective of this research work was to overcome the above complication and to establish Bilayer tablet of Glimepiride (SR) with Captopril (IR) as a once daily formulation. Method: The formulations of tablets (F1-F6) were prepared by using release retarding agents like HPMC, guar gum and xanthum gum for sustained release (SR) layer and super disintegrants like Crosscarmellose sodium, Sodium starch glycolate (SSG) for immediate release (IR) layer. Both sustained and immediate release granules were evaluated for flow property. Bilayer tablets were evaluated for weight variation, hardness, thickness, swelling index and in-vitro drug release for 12 hours. Results: There was no Chemical interaction between drug and excipients which was indicated in the FT-IR. Disintegration and dissolution profiles decreases with addition of super disintegrating agents like Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG) and polymers like xanthum gum, guar gum and HPMC. Conclusion: Among all the formulation F4 with CCS in 7.5% for immediate release and formulation F3 with guar gum in 10% for sustained release found to be best in drug release profile.

Keywords: Diabetes mellitus, Hypertension, Captopril, Glimepiride,Cross carmellose sodium, Sodium starch glucolate.


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