Abstract

IN VITRO EVALUATION OF ANTI-CANCER ACTIVITY OF SELECTED MEDICINAL PLANTS AGAINST LUNG CANCER

S. M Gopinath*, Ismail Shareef. M, Niveditha K.S, Amar Shankar

Abstract

The use of organic substances to inhibit carcinogenesis is a rapidly evolving aspect of cancer research. In present investigation the methanolic extract of Trachyspermum copticum, Coriandrum sativum, Curcuma longa, Trigonella foenum graecum and PHF (poly Herbal Formulation) was evaluated. The results obtained indicate that presences of all major phytochemicals except glycosides. The maximum antioxidant activity was reported on PHF 17.07μg/ml. Cytotoxic activity of extracts, PHF and calu6 cell lines shows 87.93 IC50 value and maximum of 76.68% inhibition for concentration of 320μg/ml. The cell cycle studies on calu6 cells and human erythrocytes, PHF shows the best results with 39.25 % gated for G2M phase. In general, it was observed that the extract of PHF was found to be more effective, the results of the present findings may be useful for the discovery of novel anticancer and antioxidant agents from the plant origin.

Keywords: Trachyspermum copticum, Coriandrum sativum, Curcuma longa, Trigonella foenum graecum, Calu6.