Abstract

ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF HIBISCUS CANNABINUS (L) SEED EXTRACT

S. R. Chaudhari*, V. R. Patil, T. A. Deshmukh,

Abstract

The petroleum ether extract of the seeds of Hibiscus cannabinus was investigated for its antinociceptive and anti-inflammatory activity in respective animal models. Significant antinociceptive was observed at higher dose of extract in writhing, tail immersion and hot plate animal models and anti-inflammatory activity was observed in carrageenan, serotonin and histamine induced paw oedema in rats. The extract exhibit significant decreased paw edema in anti-inflammatory models. Thus, the present study demonstrated that H. cannabinus seed extract has a anti-inflammatory and analgesic action against different phases of inflammation.

Keywords: Hibiscus cannabinus, Anti-inflammatory, Analgesic.