Abstract

IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF POOORLY SOLUBLE DRUG CARVEDILOL BY SOLID DISPERSION TECHNIQUE USING COMBINED CARRIERS

Abstract

In the present study attempt was made to improve solubility and dissolution rate of poorly soluble drug by solid dispersion technique using combined carriers such as poloxamer 188 and PVP K90. Carvedilol is a poorly water soluble oral antihypertensive agent. The Carvedilol belongs to BCS class II drug having low solubility and high permeability. The FTIR study indicates that there is no interaction between drug and polymer. The solid dispersions were prepared by kneading method in three different ratios viz.1:1, 1:2, and 1:4. The prepared solid dispersions were evaluated for solubility study, drug content, and in-vitro dissolution study. The prepared dispersion showed marked increase the saturation solubility and dissolution rate of Carvedilol than that of drug alone. The dispersion with poloxamer 188 (1:4) showed High solubility and faster dissolution rate as compared to the other prepared dispersions.

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