Abstract

DEVELOPMENT OF NANOSTRUCTURED LIQUID CRYSTALLINE FORMULATION OF ANTIMALARIAL AGENTS ARTEMETHER AND LUMEFANTRINE

Sunil Saini*, Gurpreet Singh, Naresh kalara, Charan Singh, Geeta, Tarun Virmani

Abstract

The main objective of the research work was to formulate a lipid based delivery system that may be useful for increasing the bioavailability of BCS class II drugs. Such type of lipid based drug carriers may keep the drug in dissolved state until the drug is completely absorbed. The present work mainly focused to formulate liquid crystalline nanoparticles in combination to improve the solubility of both ARTM and LMF which could probably improve absorption of ARTM and LMF drugs and may circumvent the drawback of poor bioavailability. In-vitro dissolution study for OF1 (F9) was carried out and it had been found that 98.00% Artemether and 89.00% Lumefantrine released within 72 hrs. OF1 was further evaluated for various parameter including organoleptic evaluation and physical stability and all are found within the acceptable ranges over a period of 3 months.

Keywords: Bioavailability, Artemether, Lumefantrine, LiquidCrystals, Nanoparticles, Organoleptic etc.