Abstract

STUDY THE ROLE OF OBESITY AND OXIDATIVE STRESS AS FACTORS OF TYPE 2 DIABETES

Edrees M.Ameen*, Hassan Y. Muhammad and Sabah N. Alwachi

Abstract

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period It is known that type 2 diabetes mellitus and obesity are bound common metabolic problems. The adipokines or adipocytokines are cytokines (cell signaling proteins) secreted by adipose tissue, their action is thought to modify many obesity-related diseases. Oxidative stress (malondialdehyde the final result of lipid peroxidation is considered a biomarker of oxidative stress) is another underlying cause of inflammation in type-2 diabetes (T2DM) playing a central role in causing late diabetic complications such as insulin resistance and impaired insulin secretion in T2DM. Materials and Methods: In the present study, 140 males with the ages between (30-60) years, 90 males of them diagnosed with diabetes type 2 and 50 of them were used as control groups. The subjects were divided into four groups, group (I) control, noneobese (25 samples): group (II) control, obese (25 samples); group (III) none-obese diabetic patients (45 samples), group (IV) obese diabetic patients (45 samples). The parameters in the present study were included Adipokines (Leptin, Resistin, and Apelin) and Malondialdehyde. Results: The study showed a highly significant (P

Keywords: Type-2 diabetes, Obesity, Adipokines, Leptin, Resistin, Apelin, Oxidative stress, Malondialdehyde.