Abstract

VITAMIN E PROTECT AGAINST NEUROTOXICITY ON RAT MODEL OF ALZHEIMER’S DISEASE

Eslam M. A. El-Nahrery*

Abstract

This study aimed to investigate the protective effect of vitamin E (VitE) on aluminum chloride (AlCl3) induced neurotoxicity in male rats. Twenty six Wistar albino rats were divided into three groups including; normal control group (n=6), Alzheimer’s disease (AD) induced (n=10) group and AD induced protected (AD-Vit E) group (n=10) orally with vitamin E dose of 300 I.U/kg b.w. daily for 12 weeks. The antioxidant status determination (TAC), lipid peroxidation (MDA), serum and brain acetylcholinesterase (AchE) activity, serum and brain homogenate C-reactive protein (CRP) assays along with histological examination were performed. The AlCl3 administration affected the brain structure and functions as it significantly decrease TAC (P < 0.001) and significantly increase AchE, CRP and MDA levels (P < 0.001). VitE administration, significantly enhanced the AD-reduced TAC levels (P < 0.001) and significantly decrease AchE, MDA and CRP levels (P < 0.001, P < 0.05, P < 0.001 respectively). Administration of VitE remarkably attenuated the AD-induced damage in hippocampus and congestion in the blood vessels of the cerebrum.

Keywords: vitamin E, aluminum chloride, acetylcholinesterase.