Abstract

THE ROLE OF THROMBOPHILIA IN RECURRENT PREGNANCY LOSS

Asaad Mohammed Ahmed Abd Allah Babker*, Salaheldein Gumaa Elzaki, Sarah Elsiddig Dafallah

Abstract

Recurrent Pregnancy loss (RPL) represents a major health problem, with approximately 15-20 % of all clinically recognized pregnancies resulting in pregnancy unhappy end. Recurrent pregnancy loss (RPL) defined as 3 consecutive pregnancy losses before 20 weeks it affects approximately 1% to 2% of women. Recurrent pregnancy loss exacts a devastating emotional toll on patients' lives. Each miscarriage brings with it a profound sense of loss and frustration. The association between thrombophilia and recurrent pregnancy loss (RPL) has become an undisputed fact. Development of thrombosis in pregnancy is multifactorial due to the physiologic changes of pregnancy which induce a relative hypercoagulable state as well as physical changes leading to increased stasis and also the effects of both the inherited and the acquired thrombophilias. In this review, we discuss the role of each of these factors on the development of thrombophilia as well as the evidence for the impact of pregnancy associated thrombosis on pregnancy outcome.

Keywords: Thrombophilia, Spontaneous abortion, Recurrent pregnancy loss.