Abstract

BUTANOLIDE, TYROSOL ESTER AND ACETOPHENONE DERIVATIVES FROM TERRESTRIAL STREPTOMYCES SPP.

Sayed A. Ahmed*, Ebtehal Taha, Islam Koriem, Emadeldin M. Kamel

Abstract

Chemical investigations of the crude extracts from the terrestrial derived streptomycete isolates Ank150, 174, and 179, yielded individually to four new compounds, namely 2-hydroxy-1-(4-hydroxy- 3-methoxy-phenyl)-ethanone (1), 1-(3,4-dimethoxy-phenyl)- 2- hydroxy-ethanone (2), acetic acid 2-(4-hydroxy-phenyl)-ethyl ester (5) and N-acetyltyrosol (7). In addition, the polyhydroxybutyric acid (PHB), reductomycin, virginiae butanolide B and tyrosol were identified. The structures of the new compounds 1, 2, 5, and 7 were determined on the basis of spectroscopic analysis (1D and 2D) and mass spectra and comparison with related structures.

Keywords: terrestrial streptomycetes, butanolides, acetophenones, natural products.