WJPR
World Journal of Pharmaceutical Research
( An ISO 9001:2015 Certified International Journal )
An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
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WJPR Citation
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| All | Since 2020 | |
| Citation | 8502 | 4519 |
| h-index | 30 | 23 |
| i10-index | 227 | 96 |
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Abstract
THE INFLUENCE OF pH ON DRUG RELEASE FROM HYDROXYPROPYL METHYL CELLULOSE MATRICESMasheer Ahmed Khan*
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, 452001, India.
Abstract The present study was focused on the effect of multimedia dissolution profile on the drug release of sustained release system of the antihistaminic agent Chlorpheniramine maleate generally used in allergic disorders, common cold and other conditions. Matrices were prepared using combination of HPMCK4M and HPMCK15M to sustain the release of the drug. Multimedia dissolution studies were performed to mimic the in-vivo condition by doing in-vitro test. The pH/buffer selection is based on the exposure of drug from stomach to intestine/colon. The study ensures the impact of pH changes on dissolution and release of drug substance for absorption. Matrices also provide quite regulated release of the drug over an extended period of time. Keywords: [Full Text Article] [Download Certificate] |
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