Abstract

A REVIEW ON TRANSMUCOSAL DRUG DELIVERY SYSTEM: AN INNOVATIVE APPROACH

*Manjusha Bhange, R. S. Pentewar, Ravi Rajurkar, Vitthal Lingayat, Seema Balurkar

Abstract

“The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity”. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. This review highlights the physiological challenges as well as the advances and opportunities for transmucosal drug delivery within the oral mucosal cavity by discussing the structure and environment of the oral mucosa and the experimental methods used in assessing buccal drug permeation or absorption also to study about novel Mucoadhesive polymers and to design improved drug delivery systems forms in efforts to achieve systemic delivery of drugs through the different mucosa. Th transmucosal drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism. Mucoadhesive polymers have been utilized in much different dosage which includes tablets, patches, tapes, films, semisolids and powders. These dosage forms include tablets, patches, tapes, films, semisolids and powders. Buccal dosage forms will also be reviewed with an emphasis on bioadhesive polymeric based delivery systems

Keywords: Transmucosal, Mucoadhesive polymer, buccal tablet, nanosponges, systemic delivery