Abstract

EVALUATION OF ANALGESIC ACTIVITY OF POLYHERBAL LEAVES EXTRACT OF ALOE VERA AND CANNABIS SATIVA IN EXPERIMENTAL ANIMALS

Saurabh Doshi*, Paresh Mohan, Mahaveer Prasad Kabra, Sandeep Singh

Department of Pharmaceutical Chemistry, Kota College of Pharmacy, Kota, Rajasthan.

Abstract

The purpose of this investigation was to study the analgesic property of the polyherbal leaves extract of aloe vera and cannabis sativa combination in rats. Anti-inflammatory activity of this combination was reported, so that extract combination may be have analgesic activity. Here, we have taken polyherbal leaves extract of aloe vera and cannabis sativa combination to determine analgesic activity. Dose of the polyherbal leaves extract of aloe vera and cannabis sativa combination were selected 100mg/kg and 200mg/kg. The analgesic activity of that extract combination was studied using hot-plate method, tail clip method and tail-immersion method in mice and rat respectively. The extract combination at all the doses used and the diclofenac sodium (100 mg/kg, i.p.) significantly increases the analgesic activity for hot plate, tail clip and tail immersion method. The analgesic activity in the extract combination treated animals was found to be significantly higher in all the models compared to vehicle control animals. diclofenac sodium (100 mg/kg, i.p.) produced a significant analgesic activity when compared with the control group. The analgesic activity of polyherbal leaves extract of aloe vera and cannabis sativa combination was however, less than that of diclofenac sodium.

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