Abstract

“EVALUATION OF ANTIDEPRESSANT ACTIVITY OF AQUEOUS EXTRACT OF ROOTS OF ACORUS CALAMUS IN ALBINO MICE”.

Dr. Shashikala GH, Dr. Prashanth D*, Dr. Jyothi CH, Dr. Imran Maniyar, Dr. Manjunath H

Abstract

Objectives: To evaluate the antidepressant activity of aqueous extract of Acorus calamus in mice. Materials and Methods: A total of 72 albino mice were included in the study. Six groups of six animals in each group were taken in each of the behavior despair models [forced swimming model (FSM) and tail suspension model (TSM)]. Three groups of mice received aqueous extract of Acorus calamus (at doses 100, 150, 200 mg/ kg body weight), two groups received standard drugs (imipramine 15 mg/kg and fluoxetine 10 mg/kg) and control group received normal saline. Antidepressant activity (i.e., Immobility time) was assessed after 30 minutes of administration of drugs intraperitoneally. Data was analyzed by ANOVA statistical test (with p

Keywords: Depression, Acorus calamus, Imipramine, Fluoxetine, Forced swim model and Tail suspension model.