Abstract

ANXIOLYTIC ACTIVITY OF LEAVES EXTRACTS OF CORDIA MYXA L. IN MICE AS EXPERIMENTAL MODELS OF ANXIETY.

Kanika Arora, Geeta Deswal*, Ashwani Dhingra, Priyanka Kriplani, Gaganpreet Kaur

Abstract

Cordia myxa L. belonging to family Boraginaceae has been used traditionally for treatment of various neuro disorders. Yet, the plant has never been subjected to systematic biological investigation. In the present investigation, various extracts of Cordia myxa leaves were prepared by successive Soxhlet extraction and were evaluated for antianxiety activity in mice using elevated plus maze test (EPMT) and light and dark test (L and DT). Each extract were administered orally in three different doses i.e. 100mg/kg, 200mg/kg and 400mg/kg, and the anti-anxity effect was compared with standard drug diazepam (2.0mg/kg, orally). Among all the extracts, only methanol extract exhibited significant anti-anxiety activity at a dose of 200 mg/kg with respect to control as well as standard drug.

Keywords: Cordia myxa; Boraginaceae; Anxiolytic; Diazepam; Elevated plus maze.