Abstract

PROTECTIVE EFFECTS OF SOLANUM LYCOPERCICUM FRUIT EXTRACT IN CYCLOPHOSPHAMIDE INDUCED GENOTOXICITY IN SOMATIC CELLS OF MICE

Srivani K., Rudrama Devi* and Minny Jael P.

Abstract

In the present investigation the antimutagenic effect of solanum lucopercicum fruit extract has been evaluated against cyclophosphamide induced genotoxicity. Single IP administration of Solanum lycopercicum fruit extract at various doses i.e. 250, 500 and 1000 mg /kg. When treated individually did not induce chromosomal aberration in bone marrow cells of mice. A single I P of 50mg/kg of cyclophosphamide induced significant increase in the percentage of micronuclei in bone marrow cells of mice. However after co administration of three doses of Solanum lycopercicum fruit extract there was a dose dependent decrease in the % of chromosomal aberrations was observed. Thus the results clearly indicate the preventive effects of Solanum lycopercicum fruit extract against CP induced genotoxicity in bone marrow cells of mice. Therefore the data indicate that SL fruit extract is a safer dietary component in cancer chemo preventive strategy.

Keywords: Solanum lycopercicum fruit extract (SLFE), Cyclophosphamide, bone marrow cells.