Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF FROVATRIPTAN

*Sirisha Yella, V Lokeswar Babu ,Dr. Avanapu Srinivasa Rao

Abstract

Fast dissolving tablets were originally developed as novel drug delivery system to dissolve rapidly in mouth without the need of water, which provide instantaneous disintegration of tablet after putting on tongue, their by release the drug in saliva. The bioavailability of some drugs may be increased due to absorption of drug in oral cavity and also due to pregastric absorption of saliva containing dispersed drugs that pass down into the stomach.The present research focuses on concept of development of Frovatriptan as fast dissolving tablets and various evaluation techniques. The aim of this study is to prepare fast dissolving tablets using Frovatriptan as a model drug for immediate disintegration and absorption and drug release characteristics in saliva. The formulation is based on preparation of fast dissolving tablets with three different superdisintegrants such as sodium starch glycolate, cross povidone and cross carmellose sodium used in different concentrations and formulated by different methods as wet granulation, direct compression and solvent evaporation techniques to get the desired release profile within minutes. The characterization studies were performed by conducting drug excipient compatibility studies by FT-IR. All formulations were evaluated for micromeritic properties, physical parameters like weight variation, hardness, friability, drug content etc., drug release & invitro drug release profile. It is concluded that the fast dissolving tablets of Frovatriptan were successfully formulated with superdisintegrants for immediate release and shows increased bioavailability and decreased first pass effect.

Keywords: Frovatriptan, fast dissolving tablets, sodium starch glycolate, cross povidone, cross carmellose sodium.