Abstract

PREPARATION AND CHARACTERIZATION OF COMBINED DOSAGE FORM OF ATENOLOL AND INDAPAMIDE TABLETS

Ashutosh Badola* and Kausal Kishore Chandrul

Abstract

The control of blood pressure is required in patients with hypertension to produce the maximum reduction in clinical cardiovascular end points, especially in patients with co-morbidities like diabetes mellitus where more aggressive blood pressure lowering might be beneficial. Recent clinical trials suggest that the approach of using drugs combined therapy for Hypertension gives significant contribution to the global health for the control of hypertension. In the present study we have formulated (f1 to f 6) matrix tablets of atenolol and Indapamide for the management of hypertension. As in studies we found that these drugs show confined release in combined formulated product. The formulation of SR matrix tablet was done by using different concentration of delayed release agent. Preformulation studies were performed prior to compression. The compressed SR matrix tablets were evaluated for weight variation, hardness, friability, drug content release for drugs in 24 hours respectively. The stability studies were carried out for the optimized batch for one months and it showed satisfactory results. The kinetic studies of the formulations revealed that diffusion is the predominant mechanism of drug and release follows Zero order rate which is a sustained drug delivery system.

Keywords: Hypertension, Preformulation, friability, drug content, matrix.