Abstract

FORMULATION AND EVALUATION OF TASTE MASKED CACHETS OF KETOPROFEN

G. Gnanarajan* and Kausal Kishore Chandrul

Abstract

Ketoprofen is bitter in taste and is omitted by mostly children. Therfore an attempt has been made to prepare ester prodrug using ethyl alcohol and its bitter taste is masked by using  cyclodextrin. The prepared prodrug is characterized by melting point UV and IR spectroscopy. We also prepared cachets of ketoprofen using - cyclodextrin as taste masking agent. Sodium carboxy methyl cellulose used as suspending agent, citric acid monohydrate used as pH modifiers. The prepared cachets bitter taste intensity was evaluated using volunteers by comparison of test samples with standard solution containing quinine at various concentration.

Keywords: Ketoprofen, Ester prodrug, Taste masking.