Abstract

NEUROPROTECTIVE EFFECT OF ACETOGENIN ON EXPERIMENTALLY INDUCED CEREBRAL ISCHEMIC RATS

Kiran Narkhede and Anandrao R Kulkarni*

Abstract

Aim of the present study was to investigate the possible neuroprotective effect of acetogenin in experimentally induced cerebral ischemic rats. Cerebral ischemia was produced by bilateral common carotid artery occlusion (BCCAO). Results indicated that cerebral ischemia group developed a significant infarction and oxidative stress which indicates that cellular leakage and loss of functional integrity of cell membrane in brain. The different doses of acetogenin have significantly improved the altered levels of lipid peroxidise (LPO), acetyl cholinesterase (AChE), reduced glutathione (GSH) and total protein levels in treatment groups which prior undergone occlusion procedure for 10 min in rat. The results obtained here study suggested that the neuroprotective effect of acetogenin was mediated through the antioxidant, free radical scavenging activity and also return of biochemical marker level near to normal values. Histopathological observation supports the prevention in architecture of the brain due to the treatment with acetogenin against occlusion induced cerebral ischemia in rat. The finding of the present study provides the strong evidence of acetogenin may be beneficial in the patient suffering from stroke (cerebral ischemia) due to various reasons.

Keywords: Acetogenin, neuroprotective, carotid artery occlusion, cerebral ischemia, acetyl cholinesterase.