Abstract

DESIGN, DEVELOPMENT AND IN VITRO EVALUATION OF INDOMETHACIN TABLET IN TABLET FORMULATION AS A PULSATILE DRUG DELIVERY SYSTEM

Swati B. Rathod*, Manoj M. Bari, Dr. Shashikant D. Barhate.

Abstract

The objective of present investigation was to develop press coated indomethacin tablet in tablet formulation using hydrophilic polymers. The drug delivery system designed to deliver the drug at such a time it could be most needful to patient of rheumatoid arthritis. The press coated tablets containing indomethacin in the inner core was formulated with an outer shell by different weight ratio of hydrophilic polymers HPMC K4M and lactose. The release profile of press coated tablet exhibited a lag time followed by burst release. The optimized F3 batch gave drug release 99.62% which consisted of 35% HPMC K4M.

Keywords: Press-coated tablet, lag time, HPMC K4M, rheumatoid arthritis, pulsatile drug delivery.