Abstract

DESIGN OF A GASTRORETENTIVE SYSTEM OF AN ANTIEPILEPTIC DRUG USING FACTORIAL DESIGN

Geeta Vikram Yadav*, Sushma R. Singh

Abstract

Introduction: Gastroretention of drugs with problems like absorption window in stomach or upper part of duodenum, instability in alkaline pH, short half-life has proven to be more therapeutically efficacious because of increased retention time in stomach. Materials and methods: Detailed Drug-excipient compatibility studies were performed at different temperature and humidity conditions. Swellable polymers like HPMC and Ethyl cellulose were used for preparation of matrix tablets with effervescent materials like sodium bicarbonate and Citric acid anhydrous. Direct compression was used for preparation of matrix tablets. 22 Factorial Design was utilized to optimize the polymer concentration. Also, In-vivo Gastroretention study has been performed in rabbit. Result and discussion: Carbopol 971P and Citric acid monohydrate were found to be incompatible with Lamotrigine. The quantities of HPMC and Ethyl cellulose were optimized. The tablet was found to be sufficiently floating in rabbit. Conclusion: The matrix tablets with sufficient floating time and sustained release upto 24 hrs were successfully prepared.

Keywords: Matrix tablets, Swelling Index, Carbopol 971P, Factorial Design.