Abstract

PREVALENCE OF HYPOTHYROIDISM IN RECURRENT PREGNANCY LOSS

Anshu Singh, Kalpana Singh and Nisha Rani Agarwal

Abstract

The aim of this study is to determine the frequency of hypothyroidism in females with recurrent pregnancy loss in Indian population and to determine the association between thyroid antibodies and miscarriage. Material and methods: The study is cross sectional, which included 103 females with recurrent pregnancy loss (RPL) and the control group consisting of 100 healthy pregnant women without history of abortion. All pregnant and non-pregnant women with a history of two or more consecutive miscarriages verified by a pregnancy test or ultrasonography, in the age group of 21–35 years were included in the study. Blood samples was collected in plain vials from patients with RPL and controls. Each blood sample was analysed for thyroid hormones T3, T4, TSH and anti-TPO Data collected and analysed. Results: In present study hypothyroidism was detected in 21 of females with recurrent pregnancy loss. In the control group 9 patients had hypothyroidism while 91 were euthyroid.TPO antibodies were positive in 18 patients in RPL patients and 10 controls. In the RPL group 3 patients were euthyroid with positive antibodies while 15 hypothyroid patients showed TPO positivity. In control group 4 patients were euthyroid with positive antibodies while 6 were hypothyroid with positive antibodies. The prevalence of thyroid autoimmunity was 17% in RPL patients and 10% in the the control group. Conclusion: The prevalence of hypothyroidism in females with recurrent pregnancy loss is more than that found in healthy pregnant females.

Keywords: In the RPL group 3 patients were euthyroid with positive antibodies while 15 hypothyroid patients showed TPO positivity.