Abstract

DIFFUSION SUSTAINED RELEASE MATRIX TABLETS OF LOSARTAN POTASSIUM BY SELECTING DIFFERENT GRADES OF HPMC AND GUAR GUM AS RETARDING POLYMERS.

B. Dileep*, B.Ramarao, G.Chiranjeevi, Ramyasri.S

Abstract

In the present work, an attempt has been made to develop Diffusion sustained release matrix tablets of Losartan potassium by selecting different grades of HPMC and Guar gum as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F3 formulation showed maximum % drug release i.e., 97.3 % in 8 hours hence it is considered as optimized formulation. Whereas the formulation containing HPMCK100M showed more retarding with increasing concentration of polymer. The formulations with Guar gum were unable to produce the desired rug release pattern.

Keywords: Losartan potassium, HPMC K15M, HPMC K100 M, Guar gum, Sustained release tablets.