Abstract

MMP-2: MOLECULE IDENTIFICATION AND STRUCTURE ANALYSIS

Pratap Shankar*, Rahul Kumar, Dheeraj Kumar Singh, Amod Kumar Sachan, S.N. Sankhwar, Rajendra Nath, Rakesh Kumar Dixit

Abstract

The upregulation of MMPs can cause several types of diseases. The cancer is main deadly disease caused by the MMPs. Different types of MMPs which are secreted by body itself to maintain the some useful activities. But the imbalance can cause some harmful effects. So to inhibit the activity of MMPs there are several inhibitors are also secreted in body itself. But sometimes these secreted inhibitors are insufficient in quantity and needed from outside as the drug. Several MMP inhibitors are available in nature as natural inhibitors and some synthetically derived known as synthetic inhibitor. So the first step to develop synthetically in laboratory we must know about structural components of the MMPs. Here we explored computationally the structural component of the MMP-2 by freely available web facilities as database, software etc.

Keywords: MMPs, MMP-2, Prostate cancer, Structural components, In-silico.